Not really a shotgun, but my Taurus Judge fires .410 shells. I keep it right by my bed, the first two rounds are .410 with the follow ups being .45lc. I know the .410 isn't lethal at long range, but the distance from my bed to door it'll at the very least hurt like nothing else. I've opted for this over a traditional shotgun by the bed because it's a lot quicker to draw and fire. I do have a JW Tolley 8Ga in the closet though, if the intruder doesn't break into my room directly I'm going for that. 2 ounces of shot per barrel is enough to send em packing. If the shot and black powder burns don't, the horrific bang and muzzle flash sure will.
Now before you go, a 12ga magnum would work just as well I'd like to explain. First of all with a double barrel there's no issue's with jamming, or having to rack another shell into the breech. I only get two shots, but having fired this thing I can honestly say the spread from one shot will clear anything standing in my hall way. It really is obvious why they made this thing illegal for hunting fowl. I really have to thank my grandfather for giving me this, and many other unique fire arms that really are unique. 96 years old and the old man's still farming (albeit not at the rate he once was).