It really depends on your choice of weapons. Charter Arms makes a nice .38 snubbie that is the only true left-handed production revolver. 1911's are great if they have an ambi safety. Semi auto's like the Glock have no thumb safety and operate like a revolver, (sort of), finger on trigger-BANG, finger off trigger-NO BANG.
The trick to successful CCW is to buy a dedicated gun belt and holster combo. A proper gun belt is heavy/stiff enough to support the gun, and a holster that doesn't allow the gun to move in the holster and keep it in place. There's nothing like reaching for your gun, and its not being where you put it to tighten up the sphincter.
I am fond of the ones from Looper Leather, in Oklahoma City. they are kydex inside and leather outside, and they look like a dress belt. The Crossbreed IWB holsters are a favorite as well.