If it a center fire weapon, which you are asking about, you should be fine dry firing it. However you should never dry fire a rim fire i.e. .22 as the firing pin will make contact with the edge of the chamber, which over time will make it difficult to impossible to chamber a round or extract a case. As a Marine Corps infantry weapons repairman, and Ordnance officer for 34 years, I never encountered a center fire weapon damaged by dry firing. As an FYI Brownells sells a tool to repair .22 chambers that have been damaged from dry firing.