MG, we are pretty much the exact same size. If you're like me, you're probably carrying a bit too much belly, which complicates things (like your damn pants sliding down).
Here's what works for me: I carry a .45 XD (full-size, not compact) in OWB Mernickle slide holster at about 5 o'clock. I find that the gun rides much better in that position than at say 3 o'clock as it kind a rides on the back of my hip and so doesn't tend to make pants slide down. I do cinch my belt fairly tight.
From this position, I can also conceal with a shirt or jacket. Depending on the fit of the shirt or sweatshirt, I might print a bit, so that might be a consideration for you. I personally do not over-worry about printing, as we don't have to "completely" conceal here in ND. With a jacket, of course, absolutely no problem.
I like the slide hoster because I usually slip my weapon into the desk drawer at work and nobody even notices the slide holster on my belt. Most probably think it's a cell phone holder or something.
I carry pretty much 24/7 and don't even notice the firearm any more. Occasionally, usually when I'm hacking around the house in my sweats, and decide to run a quick errand, I drop a S&W snubby (.38 spl) in my pocket for the quick trip.
So, there ya go, brother, that's one big man's opinion. Good luck.