trailboss
Gunsmith
Even with a suppressor larger-diameter bores generally equal more noise at the muzzle. The smaller the bore, the less noise.Ahhh but both with suppressors the .45 will make less noise as most factory .45 ammo is subsonic and most 22lr ammo is not.
Thats why a 22 is quiet without one.
True you cannot stop the subsonic boom of a 22 but the larger the projectile, the more noise it makes disturbing the air in flight.