Nope, here are some differences:
1. 15-22 is slightly wider
2. 15-22 is made of polymer
3. Take down pins are slightly farther apart on the 15-22
4. Receiver extension on the 15-22 is fake and can not be removed without permanent modification to the rifle
5. 15-22 magazine well is narrower at the top for the 22LR round, a standard AR15 magazine will not fit in it.
6. Bolt release on a 15-22 is more forward.
7. The 15-22 rear take down pin detent and spring are held in place by the pistol grip, not the receiver end plate.
8. 15-22 trigger guard is molded into lower, not a separate piece.