Howdy,
I've been carrying full size handguns for over 32 years and it's easy to do.
Nowadays I EDC a Glock 23 OWB @ 3:00 in a Glock holster, but I also have a Glock 35 ( long slide version of the 22 ) and I carry it the same way. same thing goes for my 20 10mm, 21SF .45 and Taurus PT 845 .45acp ( full size 12rds ).
I carry my Norinco 1911A1 in a belt slide holster OWB @ 3:00 as well.
Main key to carrying a full size handgun is to wear a cover garment that is long enough to cover the barrel/slide.
One thing to remember is that people are totally clueless and never look to see if a person is carrying a gun or not.
Last spring I went to a cookout were the people that were hosting the event are anti-gun and just for kicks I decided to carry multiple guns to see if they noticed. I was wearing jeans, wife beater tank top with a tan Dickie's work shirt and under it I carried my Glock 20 10mm on my right hip, a Glock 35 .40S&W on my left hip, and a Kel-Tek PF-9 in my right front pocket. 3 hours later no one noticed.
Paul