Since it appears that you are some time away from actually carrying the gun outside your home, you might as well try several guns. Caliber isn't the issue as much as feel and control. Some .380's have a sharp recoil because they are light, small, and don't fit the hand well. The same can be said about the ultra light revolvers. The heavier the gun the lighter the felt recoil is the usual rule. I have a couple of .45's that feel lighter on recoil than my .380 but are so heave they are uncomfortable to carry.
Go to a range, hold a lot of guns to see how they feel, and rent a variety of guns that felt good. Chances are you will find one that feels and shoots better than the rest. Don't expect to be too proficient at the start. If you find a gun that you are comfortable with, a local instructor should be able to help you zero in on your target.
While carrying a .22 is not going to be on the preferred list by any instructor, I doubt you will get many volunteers to let you shoot them.