It can be done and I have used them before when I can't find regular primers for my .40. Funny thing is I can't really tell a difference so maybe it has something to do with the powder. I use HB-38 and on my first attempts I reduced the charge and fired off a few rounds. They felt a little weak so I chronograph them and sure enough the were slower. I worked up the charge to something I was comfortable with and noted the powder weight on my chart for future reference. I would suggest that you start with the minimum charge for that bullet weight and work it up. As always YMMV.