Carrying a firearm is the act of giving up some comfort, for some comfort. That's my assessment after 3 years of CCW.
The question is, how much comfort are you willing to give up to get the comfort you really need?
Full disclosure: I'm the type of guy that won't wear a wristwatch because it bothers me. I wear no jewelry or trinkets, and don't like big key chains or fat wallets in my pockets.
With that said, my general advice is to err on the smaller side and don't fall for the bigger is better argument.
I thought I would buy only one or two handguns, so I started with a big 5" 1911 at 40 ounces figuring it would grow on me. Not! It got old very fast. But thankfully I found out I was a gun nut.
I eventually worked my way down, and back up to a tolerable and flat Kel-Tec PF9 at 12 ounces and a Kahr PM9 at 16 oz. Plenty of oomph in a small package, Kel-Tec doesn't possess the most confidence inspiring workmanship and materials (but very cheap so get two).
A Kimber Pro Carry II with alloy frame will fit the bill if you think a single action 1911 cocked and locked is the way to go. But that is not for everyone. Though I can handle either, I personally prefer a double action pistol with no external safeties at all and a really good holster for everyday carry.
I'm not opposed to any caliber and sometimes carry even a wimpy Walther P22 loaded with CCI stingers... You can laugh but I'd never wanna get shot with that thing. I carry all that I own for at least some period of time each year, so I am very intimate with all my little friends.
I've got quite a few now, but for carrying I consider the 19 oz Kahr 45 to be the "biggest gun" I'll ever carry ever again (Outside the Waist Band). And a Beretta Bobcat 22LR to be the smallest. (keep it anywhere you can hide it, which is just about everywhere).
Some people don't want a dozen, so do yourself a favor and start smaller rather than larger, then you will have something that you'll be able to carry under any circumstance for certain. I like the Kahr PM9 but it's not cheap, and not fun at the range either. That and the PF9 are about the smallest big guns I have. The PM45 is way too hot for my hand. Kahr is quality, and there are zero external safeties. It's like a revolver but it's a pistol... a simple and reliable self defense concept. But if you pull the trigger with your finger or other object, it will go off, no extra chances.
None of these are comfy like pajamas, except the little mouse guns come close, but many can be impossible to carry comfortably depending on body type and holster choice.
Bravo
P.S. Buy anything you want for the range, but go 100% practical and as reliable as gold for everyday carry. Plan the date of your second purchase now so you don't mess up your first purchase
When I started out, bigger sounded better, and my eyes were much bigger than what my belt could carry...
P.P.S. All the odds say that if you are unfortunate enough to need it, it will most likely happen at bad breath distance. You'll probably know you're in the fight after you hit the ground. Easy quick access may be as important as having it with you. AND! They say big guns make good clubs too. I'm not helping am I?