Try a ton of different pistols, and go with what feels best (assuming quality/reliability of course) it took me a long time to figure out what works for me, and the winner is the Smith&Wesson M&P 40c with crimson trace laser grips. If I'm dressed, I'm carrying... I use a crossbreed supertuck deluxe, and sometimes I forget it's there. I love this pistol, it functions flawlessly.
But seriously, go with what fits right, and what works for me might not work for you. For example, my DW wanted to get me a glock, (and I know their rep, and I'm not knocking them,). But I HATE how they feel in my hand.
The M&P just felt like an extension of my hand.....
Paul