I carry a 2-shot 22mag derringer in my front pocket (my hand is nearly always in my pocket, unless carrying something) but i also carry a FNS FN9 in a shoulder rig, and a G19C IWB as well
As much as I love my P22, it stays at home.
Yep, I will admit that I carry a NAA .22 loaded with .22 WMR HP. I think I can put 5 shots into someones shirt pocket if I had to.