I know guys at the range shoot their .45s at around 7-10 yds and I understand statistics in a combat or home invasion situation but I just went to the range yesterday and as normal to me, I shoot in the rifle range section and I consistently shoot out at scattered targets at 100yds. I've fired over a million rounds over the years and a book I read by Elmer Keith "Hell, I was There" about 20 yrs ago is what started me instinctive shooting and shooting with a gun in each hand or ambidextrous and shooting skeet. It was just like Elmer Keith said, ya miss a lot and then ya get lucky every now and then and then ya lucky a little more often and then ya start hitting them and over time of shooting ALOT, it will start to become regular and it did.
Now, back to the .45. Using my son's Caspian, my son shoots different then I so I had to take a few shots to see where he sits his sights and I immediately compensated. Now guys. I shot 3 deer 3 years in a row with a loose scope once and tightened it up on the 4th year so ya can't tell me ya can't compensate. Not to mention that my weapon's receiver in the military was bent and I always aimed to the left. (What? I'm not a complainer is why I didn't trade it in)
Anyway, I can consistently shoot groups out at 100 yds with several different hand guns. The thing for me is, I can hit further than that but depending on the weight and trigger pull of the individual hand gun starts to become an issue being steady and if there is a heavier trigger pull. I'm sorry but I use to quick draw at 35 yrds til I shot next to my foot once at the 35 meter and 50 meter targets but they became just not challenging enough is why I went out to 100yrds.
If you can think it, it's possible. There's always a way.