Definitely check out the M&P pistols. But since you have big hands, I'd opt for the .45 instead of the 9mm or the .40 S&W. The big deal about the M&P line of pistols is that they have interchangeable backstraps, 3 included with the gun in S, M, and L.
My husband has big hands (one of his nicknames is "Shreck"). He really likes his Sig P226 - he has it in .40 but I think it can be obtained in any of the major calibers. My son, who has hands almost as large as his Dad's (but shaped very differently - he has smaller palms but longer fingers) also has a Sig P226 in 9mm. He likes it as well.
I have fairly small hands, and I carry an M&P 9mm - I use the smallest palm swell and I find it quite comfortable and I can shoot accurately with it.
I have large hands and a big guy too (6'2" 290)
The guns I use for carry are a Sig Sauer P226 in 9mm and a Glock 26 but with a Pinky extension from Scherer (its longer than the others on the market) or I use a 15rd mag with a grip sleeve depending on what I'm wearing. But if your looking for a small gun then go with the Glock 26 and follow my changes I do
Gotta vote for the M&P... I have both the full size 45 and the 40c... Both comfortable to shoot and fit hands large and small. If they are really large (like my nephew Alex) the full size 9 or 40 will do quite well... I carry my full size M&P45 in a CrossBreed IWB and have no issue with comfort. My 2 pennies..
Two I have personal exp with is Glock 19 gen4, adjustable straps, would fit bigs hands good, also the Sig 226 is a good option, best advice would be go to a range that rents guns and shoot some find one you like,shoot well, feels good, and then buy one
I've found that my XD9 (Service model, full size) not only is a good fit for my hands, but I've got no problem concealing it. At 6'2", 300lbs, I've got plenty of space to hide it, though. Nice weapon, fits well.