The wife has one. Getting our CCW seemed like a fun thing to do as a couple, so we bought a pair of guns and did that. She has a criminal justice degree, but isn't using it, so she's had some interest. I'd never fired a handgun before, but used to shoot rifles 20 some years ago.
We don't get out much to shoot right now as she's been too busy, but looking forward to going out to the range again later on this year!
Does bring up one point. She ended up with one of the smaller S&W M&P 9mm. Fits her hand great, works very well for her, except for one problem. It's a bear to rack the thing. It's nearly impossible for her, and I struggle with it too. Smallish gun, stiff spring, small gripping surface, and it's slippery. Had a couple local NRA Instructors as well as LEOs advise us on technique, but it's a simple lack of brute force issue. Bigger stronger people than us struggle with it too! Any ways to make it more usable for her? I don't like the fact that I have to rack it for her each time (not to mention I've already had one slip while racking that tore a chunk of skin off a finger)...