I never change positions of my holster, on my hip with my trigger lined up on my pants leg seam. If i need to reach for my weapon, i want it to be where my muscle memory/habit expect it to be, and my tactical response aren't altered.
I Draw my weapon straight up to my arm pit, ready... shoot, or extending the arm to a more aimed position. That's how i train, that's how i go about my day ready to react.
Except foe special occasions where clothing restrictions may occur, i may go to my ankle holster.