Handcuffing is a bad idea on many levels, despite how tempting it may seem in a scenario like this homeowner from PHX experienced.
First, one of the cardinal rules in law enforcement is to never have two tools in your hands at the same time. (Flash light doesn't count.) Any one who saw the video of the LEO who shot & killed 22 year old Foster Grant by an Oakland, CA train on New Years saw a violation of this cardinal rule. Grant is dead, and the LEO's life and career are over. (Charged with homicide and going to prison as LEO... no thanks.) I'm not saying you WOULD shoot someone unintentionally while cuffing, but it's a cardinal rule for a reason. (Sympathetic muscle reflex - same reason you stay off your trigger until you're on target.)
If you're the homeowner in a scenario remotely similar to the one that started this thread, you would HAVE to use both a gun as a defensive/covering tool and try to handcuff your BG by yourself. Highly unenviable task, even for the pro who has mastered speed 'cuffing. Even if the BG is 'cooperative.' If he's not, and he's struggling to resist your cuffs and YOU... forget cuffs, man.
Second, if you have to set your gun down to effectively handcuff your BG, he may instantly decide to NOT be so cooperative and repentant once he realizes you removed your own advantage.
Third, while most states that have castle doctrine will lawfully permit you to dispatch this home invander into eternity, many states are not so tolerant of citizens handcuffing other citizens - even criminals. Would you get charged for it? Who knows, in this day and age. BUT - say you DO handcuff the dirtbag and the RO's show up and take him away and you're the hero of the block... until the dirtbag SUES YOU for injuries sustained from your improper/untrained handcuffing technique that resulted in dibilitating injuries to his hands/wrists. Now what? Hire a civil lawyer to defend your use of 'cuffs? Screw that.
Something to think about in home defense planning. Don't make a bad and dangerous situation worse. Leave the 'cuffs in the bedroom.
leasantry: