Welcome to this forum. A lot of information you seek can be found in the sub-forum
Link Removed, as well as, at
Cornered Cat.
Your post does not provide much context. Has she ever shot a handgun before? What is her experience with firearms in general? Where does that weak wrist fear come from? (Is there an actual physical condition?)
My recommendation, find a local range that rents guns and that has a handgun safety class for women, may be even a shooters club for women. There are many variables in play when it comes to handguns for concealed carry, none of which matter if she doesn't learn the basics of safely operating a firearm. A good instructor will help overcoming initial fears and will train her the correct technique. A 22lr revolver and/or a 22lr semi-auto handgun are good tools for initial training. A few trips to the range and renting different handguns will also help narrowing down the decision on the carry gun. Experience comes with training and practice! Wandering through a gun store and picking a gun based on a store clerk's recommendation is a good way to waste money.
Handgun type, caliber/cartridge, size, capacity and other factors are often more about personal preference that anything else. The most important factors are: (1) will she carry this handgun and (2) is she able to defend herself using this handgun? A handgun sitting in the safe at home because it's "too big and/or too heavy" to carry doesn't do any good, neither does a handgun that she won't train with because it's "too painful to shoot".
Lastly, there is obviously the legal part of concealed carry, including acquiring a permit if needed. The most important aspects of this are: understanding the law and having the right mindset. The legal use of a firearm for self defense is limited, as it is a lethal weapon. Nonlethal means of self defense are still needed, including running away from a threat.
PS: I was at the range and at several gun stores today. At the range, a male was shooting a .44 Magnum using the "tea cup" method. Needless to say, this would be a one-shot (one-miss) scenario against a bear in the woods. Another one was teaching his wife the Mozambique drill (2 in the chest and one in the head). This was her first trip to a range and the first time handling a firearm. I constantly heard "Ouch, this hurts!" (from the recoil), "Is the safety on?", and "Is it loaded?". The gun store clerks again did their best today to sell firearms and accessories to clueless customers. One did actually buy the Gander Mountain warranty on a new firearm.